The neighborhood of Alzheimer's amyloid precursor protein: new clues on Alzheimer's pathology from other proteins linked to amyloid plaque formation
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چکیده
The identification of amyloid-rich plaques has long been a diagnostic tool for pathologists investigating Alzheimer's disease (AD). The plaques are formed through the accumulation and aggregation of beta-amyloid peptides derived from the amyloid precursor protein (APP; see figure) and are characteristically found in the brain parenchyma and around blood vessels. Although it is clear that APP plays a role in AD pathology, the normal function of APP is currently unknown.
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